The purpose of this study was to examine the psychometric properties of the Acceptance and Action Questionnaire for Weight-Related Difficulties (AAQW) among Hispanic college students (n = 313). Results from exploratory and confirmatory factor analyses supported a 1-factor, 6-item solution, which we call the AAQW-6. Additionally, psychological inflexibility for weight-related difficulties was associated with higher levels of disordered eating and general psychological inflexibility and lower levels of mindfulness. The AAQW-6 added to prediction of disordered eating above and beyond body mass index (BMI) and general psychological inflexibility. This study provides initial psychometric support for using the AAQW-6 with Hispanic college students. Future studies should replicate the factor structure and related psychometrics of the AAQW-6 and further determine whether it allows clinicians and researchers to predict and influence relevant behaviors in the lives of individuals across demographics, Hispanic and otherwise. (PsycINFO Database Record (c) 2019 APA, all rights reserved)