Article Correctness Is Author's Responsibility: How Does Ketamine Combat Depression? December 16, 2020 Author: Neuroscience News Category: 4E-BPsThe article below may contain offensive and/or incorrect content. 4E-BPs proteins are key to unlocking ketamine's antidepressant effects. When 4E-BPs are absent in neurons, ketamine can not produce its antidepressant effect.